does semaglutide help anxiety Study links and tirzepatide to fewer and depression diagnoses in obesity care Study: Some GLP-1s may lower

Pratley R, Amod A, Hoff ST, Kadowaki T, Lingvay I, Nauck M, Pedersen KB, Saugstrup T, Meier JJ., PIONEER 4 investigators

Key Points Your body takes about 5 weeks to completely eliminate semaglutide after your last dose, with effects gradually wearing off during this period Clinical studies show people typically regain two-thirds of their lost weight when they stop taking semaglutide medication Work with your healthcare provider to gradually reduce doses instead of an abrupt stop A nutritious diet and exercise can help you manage semaglutide withdrawal symptoms Your body adapts to semaglutide over time, creating changes that don't simply reverse when you stop

Try to stick to whole, nutrient-dense foods to keep your energy steady

Some patients may need to restart at a lower dose after a longer treatment break