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That stems in part from experience with an earlier weight-loss drug from Sanofi called Acomplia/Zimulti (rimonabant), which was approved in Europe in 2006, but withdrawn from sale two years later after the EMA concluded it was associated with a risk of serious psychiatric problems, including suicide

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However, the interaction between these medications requires thoughtful consideration due to semaglutide's effect on gastrointestinal motility