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pH extremes destabilize the copper complex

GHK-Cu is a copper-binding peptide with various biochemical effects

Abbreviations MASLD : Metabolic dysfunction-associated steatotic liver disease MASH : Metabolic dysfunction-associated steatohepatitis T2DM : Type 2 diabetes mellitus GLP-1 RAs : Glucagon-like peptide-1 receptor agonists GIP : Glucose-dependent insulinotropic polypeptide GCG : Glucagon AACE : American Association of Clinical Endocrinology AASLD : American Association for the Study of the Liver Diseases F2 : Fibrosis grade 2 ABCD : Adiposity-based chronic diseases EASO : European Association for the Study of Obesity VAT : Visceral adipose tissue FFA : Free fatty acids HSC : Hepatic stellate cells FDA : Food and drug administration F3 : Fibrosis grade 3 AST : Aspartate aminotransferase ALT : Alanine aminotransferase GGT : Gamma-glutamyl transferase NAFLD : Non-alcoholic fatty liver-disease LFC : Liver fat content MRI-PDFF : Magnetic resonance imaging derived proton density fat fraction ELF : Enhanced liver fibrosis FIB-4 : Fibrosis-4 index F1 : Fibrosis grade 1 NAS : NAFLD activity score AE : Adverse event SAE : Serious adverse event EMA : European Medicine Agency FGF21 : Fibroblast growth factor 21 MetALD : Metabolic dysfunction and alcohol-related liver disease References Le MH, Le DM, Baez TC, Wu Y, Ito T, Lee EY, Lee K, Stave CD, Henry L, Barnett SD, Cheung R, Nguyen MH