napqi glutathione mechanism 5️⃣ Antidote: NAC (N-acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. 🟢 Example: Hospitals use NAC as the standard treatment for APAP overdose Metabolism of paracetamol at recommended/therapeutic

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Betz RC, Petukhova L, Ripke S, Huang H, Menelaou A, Redler S, Becker T, Heilmann S, Yamany T, Duvic M, Hordinsky M, Norris D, Price VH, Mackay-Wiggan J, de Jong A, DeStefano GM, Moebus S, Bhm M, Blume-Peytavi U, Wolff H, Lutz G, Kruse R, Bian L, Amos CI, Lee A, Gregersen PK, Blaumeiser B, Altshuler D, Clynes R, de Bakker PIW, Nthen MM, Daly MJ, Christiano AM (2015) Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci

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The level of Cu was 20% lower in men than in women (102)