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Deficiency can contribute to symptoms like irritability, mood swings, or even depression

The Mounjaro label includes warnings for severe gastrointestinal adverse reactions, acute kidney injury due to volume depletion, acute gallbladder disease, and diabetic retinopathy complications in certain patients

Cell 130 , 10571070 (2007)

Rachel Hall, Principal Doctor at Second Nature Our research at Second Nature shows that fatigue typically follows a predictable pattern: Weeks 1-4: Nearly half of patients (44%) report increased tiredness Weeks 5-8: Fatigue significantly improves, with only 22% still reporting tiredness Beyond week 12: Most patients return to normal energy levels as the body adapts For some patients, tiredness can persist longer, particularly if theyre not consuming adequate nutrition or have underlying issues like poor sleep habits or nutrient deficiencies