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And you can solve that problem with adding a little bit of T3 or balancing those hormones and then later removing it and seeing if they can get by on their own

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Expression of GLP-1R V229A was again associated with significantly improved insulin secretion fold-increases to exendin-4, but in this case no changes were detected under 11 mM glucose alone conditions, with the improved fold being a consequence of enhanced insulin secretion versus WT GLP-1R during the exendin-4 stimulation period (Figure 8H, I)

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