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The metformin intervention also plays a role in glycerol-3-phosphate dehydrogenase and selectively inhibits the substrate (glycerol and lactate) involved in hepatic gluconeogenesis (Lamoia and Shulman, 2021)

If GI side effects are still significant at your current dose, more time is the answer, not a higher dose

A study published in May 2024 found that men with obesity who were taking semaglutide, the active ingredient in Ozempic and Wegovy, were actually at a slightly higher risk of erectile dysfunction than men with obesity who werent taking the drug

The earliest realistic estimate for MHRA marketing authorisation is late 2027 or mid 2028