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The side effect profile of GLP-1-RA includes delayed gastric emptying which may put surgical patients at an increased aspiration risk, even if proper fasting guidelines have been followed

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Horizontal positioning worsens nausea from slow gastric emptying

The search strategy included the terms: (inflammatory OR inflammatory response OR cytokine) AND (perioperative neurocognitive disorder OR postoperative cognitive dysfunction OR postoperative cognitive impairment OR postoperative cognitive decline OR postoperative cognitive disorder) AND (general anesthesia OR anesthesia OR surgery OR operation). Studies investigating the association between inflammatory markers and perioperative neurocognitive disorder were included