Therefore, complete protein is mainly provided by eating a variety of fermented dairy products, eggs, and lean white meat [14]
Although the actual mechanisms of MTX-induced liver and kidney damage are unknown, one of the hypotheses is the breakdown in cellular antioxidant defences, which increases the production of reactive oxygen species and nitrogen species, inhibits cytosolic NADP-dependent dehydrogenase and NADP malic enzyme, lowers glutathione (GSH), superoxide dismutase (SOD) and catalase levels and reduces the effectiveness of the antioxidant defence system protecting the cell against reactive oxygen species (Reference Savran, Cicek and Doguc7)
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Various studies have shown that SGLT2 inhibitors promote autophagy by using mTOR-AMPK-mediated pathways, which, in turn, help protect the kidneys against various types of renal damage (264266)