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Pharmacovigilance status of DPP-IV inhibitors With an ideology to work on the crux of the matter, DPP-IV to manage diabetes, orally active small molecules called DPP-IV inhibitors have already been introduced in the market since 2006 ( Figure 2 )

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As a result, Tyk2 knockout mice exhibited reduced proliferation of autoreactive CD8+ T cells and impaired cytotoxic activity against cells ( IFIH1 and TYK2 modulate the response of the immune system to pathogens and inflammatory signals, other genetic factors shape the direct interaction between the host and the environment

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