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Rekindling vitamin C cancer therapy: oral vs intravenous administration Based on studies pioneered by Mark Levines group at the NIH in the 2000s, the oral vitamin C doses used in the Mayo Clinic studies would have produced peak plasma concentration of less than 200 M
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Thus, chemotherapeutic approaches to blocking DNA replication through disruption of disulfide reductase pathways will need to be cognizant of the potentially complete functional redundancy of the GSH and Trx pathways in animal systems, and sensitive to the various other physiological roles these pathways play in normal homeostatic and stress-response pathways
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