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There's so much that depends on this, including genetic factors, our nutrient status, that this is why we need to be looking at the big picture

Because the liver stores several years' worth of B12, symptoms often creep in gradually, which is one reason the condition is underdiagnosed

Biotechniques 40, 790798

Pioglitazone Low dose pioglitazone treatment can significantly reduce fasting blood glucose and malondialdehyde levels, improve tissue damage caused by diabetes, enhance antioxidant activity and reduce apoptotic activity, and have beneficial effects on spermatogenesis and steroidogenesis in adult diabetic rats (Hasan et al