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In the case of bacterial meningitis, one has to consider the following cumulative effect of several pathophysiological factors: The damage to neurons results from the release of reactive oxygen species (ROS), caspases, proteases, cytokines and excitant amino acids after the activation of transcription factors

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Most interestingly, the seasonality of phases (which is typical for Moscow latitude and is associated with fluctuations in atmospheric pressure and climatic changes) in K3 was found in half of the patients, and the portion was significantly lower in comparison with K1