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The PSG report said high discontinuation rates are now playing a major role in coverage decisions, as nearly two-thirds of patients without type 2 diabetes who take GLP-1s discontinue treatment within one year. In addition, 72% of those surveyed indicated that discontinuation rates and weight regain were at least moderately influential in their GLP-1 coverage decisions. Discontinuation rates are very high and employers want to know if this will actually provide a return on their investment if they (workers) arent taking them long-term, Lee said in an interview.

Ostapcuk V, Mohn F, Carl SH, Basters A, Hess D, Iesmantavicius V, et al

Consumption of NADPH for 2-HG synthesis increases pentose phosphate pathway flux and sensitizes cells to oxidative stress