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[17] [11] The decision to use these medications together would be considered off-label in the UK and should only be made by a qualified healthcare professional after careful assessment of individual patient factors, including cardiovascular health, psychiatric history, and current medications

Table 4 Recommendations for policymakers and healthcare systems

Ligands are small proteins that tell cells to carry out certain tasks

In this review, we discuss several cellular processes, such as autophagy, endoplasmic reticulum stress, mitochondrial dysfunction, macrophage polarization, ferroptosis and the Th/Treg cell balance, which are associated with the occurrence and development of UC