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To determine the activity and at the same time the cellular level of oxidative stress, it is necessary to assess specific biomarkers, namely: Superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant capacity, malondialdehyde, low-density lipoprotein (LDL)-oxidized, and anti-oxidized LDL antibodies
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Pretreatment of RAW 264.7 macrophage cells with GHK-Cu has been shown to significantly decrease ROS levels induced by lipopolysaccharide (LPS), increase levels of SOD activities and total GSH, and decrease levels of TNF- and IL-6 production through the suppression of NF-B p65 and p38 MAPK signaling [22]
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