It is, therefore, important to have liver-specific treatments for patients who have already advanced liver disease
Possible reasons include Type 1 diabetes diagnosis, advanced Type 2 diabetes with severely depleted beta cells, contraindication to GLP-1 drugs (thyroid cancer history, pancreatitis history), insurance or cost barriers, prior GLP-1 intolerance, or very high blood sugar requiring immediate insulin coverage
Therefore, they are nowadays recommended as first line therapy in patients with T2DM and atherosclerotic cardiovascular disease to reduce events, regardless of baseline or target HbA1c and concomitant glucose-lowering medication according to the 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes [31]
Your doctor can help you restart semaglutide safely, usually by beginning with a low dose again