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In a typical case, the former will show typical melanocytes with an increased volume of melanin pigment that can be distributed throughout the epithelium and the latter will show increased melanin deposition along the basal cell layer, atypical melanocytes with nuclear pleomorphism, hyperchromatism, and the absence of rete ridges in the affected tissue

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Dipeptidyl peptidase-4 inhibitor Inhibitors of dipeptidyl peptidase 4 ( DPP-4 inhibitors or gliptins ) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4)

243 In the local islet environment, a high concentration of somatostatin creates an inhibitory milieu, further reducing the activity of -cells and the secretion of glucagon