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The importance of TNF- can be explained by the fact that mutation of TLR-4 affects patients development of sepsis and its degree due to different responsiveness of lipopolysaccharide (LPS) ( exerts its effects by activating the intracellular signaling pathway NF-B, further stimulating the multi-protein complex, NOD-like receptor protein 3 (NLRP3) inflammasome ( in the endothelial and vascular smooth muscle cells ( coactivator-1 and inhibition of mitochondrial ROS production ( Glucagon-like peptide-1 receptor (GLP-1R) is widely expressed G protein-coupled receptor, mediates the effects of Glucagon-like peptide-1 (GLP-1), a peptide derived from proglucagon and produced in intestinal L-cells, pancreatic -cells, and specific brain regions ( Despite the rapid expansion of GLP-1RAs applications in fields such as endocrinology, cardiology, and neurology, their potential relevance in sepsis remains relatively underrepresented in the literature

Lukitaningsih, E., Rohman, A., Rafi, M., Nurrulhidayah, A

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