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Normal serum bicarbonate: 2228 mmol/L Physiological Role Maintains blood pH (~7.357.45) Buffers metabolic acids Works with lungs and kidneys in acidbase regulation Buffer equation: CO + HO HCO H + HCO Regulation Lungs Control CO (acid component) via ventilation Kidneys Reabsorb filtered bicarbonate Generate new bicarbonate Excrete hydrogen ions (H) Clinical Uses of Bicarbonate (Sodium Bicarbonate) Indications 1

In Situ Metabolic Characterisation of Breast Cancer and its Potential Impact on Therapy