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Glutathione helps reduce this stress by neutralizing free radicals produced during intense or prolonged physical activity

GI inflammation: Inflammatory gastrointestinal disorders like leaky gut, celiac disease, and other inflammatory bowel diseases can influence the ability of the body to eliminate histamine

4.2 Diabetes Oxidative stress not only directly harms islet beta cells but also acts as a signaling molecule that activates various stress-sensitive pathways

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization