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& Deponte, M

Free Radic Biol Med 53:437446

In addition, the expression levels of several genes associated with apoptosis were upregulated in the adipocyte-rich fraction isolated from eWAT or sWAT of intermittently fasted (HFD-IF) in comparison to ad libitum fed (HFD-AL) obese mice, while markers of senescence ( p16 ) and DNA-damage ( Parp1 ) were not changed (Fig

Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option