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The 2016 meta-analysis (Pooyandjoo, PMID 27335245) pooled trials of varying length and found a mean 1.33 kg difference versus control, but its meta-regression reported that the weight advantage shrank as supplementation continued so the weight effect does not compound across this window the way recovery adaptations do

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Clinical trials consistently demonstrate their efficacy in reducing major adverse cardiovascular events, making them a valuable addition to the therapeutic arsenal against obesity-related heart disease

Recently, more attention is being given to the detrimental effects of chronic low-level exposure, especially to children