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This problem is of particular importance in tissues with lower activity or concentration of Sorbitol dehydrogenase enzyme

Formation of iodinated disinfection byproducts (I-DBPs) in drinking water: emerging concerns and current issues

These effects can be broadly categorized into three functional pathways: regulation of lipid synthesis, oxidative stress, and inflammatory responses

Upon examination of total weight reduction from treatment initiation, early non-responders receiving AOM augmentation ultimately attained similar results (6.1%) to early strong responders (8.0%), with no statistically meaningful difference between groups