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DSIP should be approached with particular caution by individuals with severe psychiatric conditions, untreated sleep disorders like severe sleep apnea, or those taking medications affecting the central nervous system

A 2022 placebo-controlled study on married women suffering from severe sexual dysfunction found that 15mg of saffron twice daily (30mg total) resulted in a 62% score improvement from baseline after six weeks

It is of particular interest in the context of obesity to investigate whether this hormonal pathway is disrupted