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These multiple cellular pathways explain why GHK-Cu attracts attention, but they also make it harder to reduce the peptide to one simple mechanism of action

The pentadecapeptide structure provides moderate stability, but the compound still degrades through standard pathways when exposed to heat and moisture

Importantly, a clinical study has demonstrated that combining radiotherapy with higher doses of the TGF-blocking antibody fresolimumab (10 mg/kg) increases overall survival significantly in metastatic breast cancer patients compared to those undergoing radiotherapy and receiving lower doses of fresolimumab (1 mg/kg) [135]

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