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T2DM is characterized by a chronic proinflammatory state marked by the overexpression of cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha, alongside chemokines and other proinflammatory mediators, which contribute to insulin resistance.108 Elevated concentrations of these inflammatory cytokines have been detected in the plasma and cerebrospinal fluid of patients with AD,109 and postmortem analyses revealed an inflammatory milieu within the AD brain,110 implicating inflammation as a contributory factor in the pathogenesis of dementia

Is the blood-brain barrier really disrupted in all glioblastomas

Current incretin therapies are limited to injectable options or an oral peptide formulation (oral semaglutide) that includes absorption enhancers and mandates fasting conditions for adequate absorption