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Given the large and increasing number of currently developed novel agents within the class of GLP-1RAs (127, 128), it can be anticipated that there will be increasing competition to achieve better tolerability and safety

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To advance translational applications, future studies should focus on: (1) transforming dynamic biomarkers into clinical decision-making tools, such as evaluating early changes in circulating mitochondrial-derived vesicles or oxidative stress markers (e.g., 8isoprostaglandin F2 (8-iso-PGF2))to predict subsequent biochemical and histological responses