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Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104

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This finding explains why the accumulation of LCACs occurred in the ALF group compared with the NLF group, while the levels of SCACs and MCACs were unchanged

However, certain groups are in danger of deficiency and are at higher risk