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There are several causes of vitamin B12 deficiency, including dietary factors, medical conditions, and genetic factors

Lower esophageal sphincter inflammation/gastroesophageal reflux disease Gastroesophageal reflux disease (GERD) occurs as a result of pathological regurgitation of stomach contents into the esophagus

The active factor responsible for this rejuvenation signal was a copper-bound tripeptide that Pickart identified as glycyl-L-histidyl-L-lysine

Advertisement If you have chronic low B12 levels or have underlying health conditions that cause the deficiency, you may need to take B12 for the rest of your life (or for as long as you have the underlying condition)