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Researchers with type 2 diabetes following a retatrutide dose schedule need to monitor blood glucose closely during each escalation step, as the improved insulin sensitivity can cause hypoglycemia if diabetes medications are not adjusted accordingly

Balanced cohorts (n=169,630 each) were created using 1:1 propensity score matching

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We established an FP competition assay to biochemically validate displacement of the TIN2 peptide by the compounds and further showed that compound 40 , identified as one of the most potent analogues amongst the compounds tested, evicted full-length TRF1 from the shelterin complex by disrupting the TRF1 TRFH :TIN2 TBM interaction