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Semaglutide targets GLP-1 receptors

(The FDA has received more than 700 adverse event reports tied to compounded GLP-1s, but its not clear if the events were caused by the drugs.) The companies also see compounders as a threat to their obesity drug sales, which are estimated to balloon to $100 billion a year by 2030

Bioavailability differs between subcutaneous injection and sublingual delivery, so the numbers are not directly interchangeable

This evolution matters for the before-and-after narrative because it means the early struggle with portion control and food choices gradually gives way to effortless moderation