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Acknowledgements This work was supported by KAKENHI (26460352 and 17K08613), a Grant-in-Aid for Scientific Research to Y.K., KAKENHI (16K15123), a Grant-in-Aid for Scientific Research to N.S., and KAKENHI (26460115 and 17K08331), a Grant-in-Aid for Scientific Research, the Strategic Research program for Brain Sciences from Japan Agency for Medical Research and development, AMED, the Uehara Memorial Foundation to H.K

Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth