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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

B12 deficiency is more common than you might think, especially if you follow a vegetarian or vegan diet, have digestive issues, or are over 50

Many people dont realize just how much B12 influences how they feel until they replenish it

30 Other studies hint at effects on telomere length and cellular senescence, 31 with one trial even suggesting partial reversal of two key biological aging markers in older adults