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Taken altogether these physiological shifts can enhance sexual function for some people, even as the medications potentially continue to lower the volume on certain reward pathways

PMID 8689347

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Firstly, through a systematic review and network meta-analysis, researchers have assessed the effects of GLP-1R agonists on neuroinflammation and reported that, compared with placebo, GLP-1R agonists significantly reduce the levels of neuroinflammatory markers, such as TNF- and interleukin-1 (Urkon et al., 2025