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This complete absence of tolerability-driven discontinuations represents a remarkable safety finding and indicates that even when mild side effects occurred, they were sufficiently manageable that participants chose to continue treatment

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With regard to Nrf2 activators, such as sulforaphane and bardoxolone, the majority of evidence is currently derived from in vitro experiments or animal models of oxidative stress-related disorders, including osteoarthritis and IDD (72)

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