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Tissues and structures affected by knee OA include: The articular cartilage, a smooth surface covering the bones that reduces friction and serves as a shock absorber gradually breaks down and erodes

Several commenters provided examples of the operational burden, noting recent revenue losses, constrained resources, necessity of hiring vendor support to meet the requirements, and concern about the amount of time required for implementation

At the same time, those without a compounding license and PCAB accreditation should also be avoided