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In vivo rodent studies have reported hypoglycemia at higher amounts, consistent with the cross-reactivity of IGF-1 at the insulin receptor at supra-physiologic concentrations

Increased blood glucose monitoring is essential during the transition period, particularly checking for hyperglycaemia above 15 mmol/L and ketones if levels rise

These tissue sections were washed with phosphate-buffered saline (PBS) and incubated overnight with anti-GLP-1R (1:200, NBP1-97308, Novus Biologicals, USA) at 4 C

For individuals on GLP-1 agonists who may feel less energetic during dose escalation periods, walking is the easiest and most sustainable activity