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The behavioral consequence of this circuit is well-documented: optogenetic stimulation of VTA GABA neurons directly suppresses the activity and excitability of neighboring DA neurons [48] and, critically, this suppression disrupts reward consumption while leaving anticipatory behavior intact [49]

However, they're not appropriate for everyone, and they work best when used as part of a comprehensive approach that includes attention to nutrition, physical activity, behavioral changes, and attention to emotional eating patterns

Portions shrink

Reddys has introduced SemaKare, a comprehensive programme designed to improve treatment adherence and outcomes