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cerevisiae strain with pTEF1-GSH1 at the GSH1 locus on both alleles, and pGSH1-URA3 at the URA3 locus on both alleles was constructed (strain designated homozygous pGSH1-URA3 in the following context) (Figure S1 B )

Mean abundance and standard deviation (SD) of each metabolite were calculated for each sample group in the metabolome, and univariate analysis was performed to obtain fold changes and p-values

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