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In conclusion, the available literature in this field suggests that it is now time for the design of large-scale prospective studies, spanning over at least three different generations, in order to clarify the possible contribution of both maternal and maternal grandmother's diet and genotype to the occurrence of meiotic errors favoring chromosome 21 malsegregation and the birth of a DS child, as well as to other metabolic changes and/or epigenetic modifications leading to death in utero or to the occurrence of either congenital or age-related DS comorbidities

Retatrutide and cagrilintide remain investigational worldwide and carry no approval for human use

Individuals who are pregnant, breastfeeding, or have allergies to cobalt or B12 should consult a doctor before use

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