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Both plasma acylcarnitine and urine organic acids, however, have been observed to be normal in nearly half of RTD patients [26]

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Moreover, the therapeutic use of butyrate has been demonstrated to revert manic-like behavior in rats and regulates the antioxidant enzyme activities, protecting the brain against oxidative damage [207] therefore supporting the important role that SCFAs may play in the brain alterations in patients with BD

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