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The male-to-female ratio ranges from 1:9 to 1:20, and the onset age is typically between 40 and 50, although it can also occur in children [253]

J Drug Deliv Sci Technol 55:101466 Nie G, Cao Y, Zhao B (2002) Protective effects of green tea polyphenols and their major component,()-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells

Methionine is an essential amino acid, and selenium is an antioxidant that acts as a cofactor for glutathione peroxidase which neutralizes hydrogen peroxide (see Figure 1)

In most cases, the death of the patient is due to respiratory failure and occurs within three to five years of diagnosis