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Generation of CRISPR/Cas9-mediated knockout cells The following guide RNAs (gRNAs) were used in the study: For CSE: exon 5 (5-GGAGACATTATTTTGGTCGTGG-3) and exon 1 (5-TTCCAACATTTGGCCACGCAGG-3) (purchased from Sigma-Aldrich)

It is a reasonable step up for normal-to-resilient skin, but the incremental benefit over 1% is not dramatic and depends heavily on the quality of the surrounding formula

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