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The therapeutic advantages are ascribed to its varied pharmacological activities, which encompass anti-inflammatory, carminative, antiemetic, diaphoretic, antispasmodic, analgesic, stimulant, emmenagogue, and anticatarrhal properties [118,119,120]

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The protocol was modified and the trial resumed, but this highlights that injection site issues can be more than trivial

When Melanotan II activates MC1R , it triggers intracellular signaling (commonly described via the cAMP pathway ) that upregulates melanin-related processes in melanocytes, increasing melanin production and shifting pigmentation expression over time