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The numbers come from the STEP 1 trial of semaglutide 2.4 mg, which is the most rigorous long-term data available, with real-world variation noted where it matters

Your healthcare provider will work with you on the appropriate timeline and dose for your situation

In addition, under hyperglycemic conditions, disrupted glucose metabolism pathways generate a large number of metabolic byproducts (such as dihydroxyacetone, lactate, etc.), which, through oxidative stress, further damage the cells and genes involved in spermatogenesis [220,221,222]

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