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[3] In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, increased rate of haemolysis, and defective function of the central nervous system

But micro-dosing is a very interesting concept which has not been studied much at all

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Additionally, the accumulation of TMA and its unpleasant odour in individuals with FMO3 gene defection who suffer from fish odour syndrome diminishes the potential of FMO3 as an inhibitory therapeutic target