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Based on advancements in folate metabolism research, in 1980, scientists described the 'folate trap', a phenomenon in which the enzyme methionine synthase (MTR), in the absence of its cofactor (vitamin B12), is unable to convert homocysteine into methionine

This inhibition can lead to: Enhanced Cellular Metabolism: By inhibiting NNMT, 5-Amino-1MQ can increase levels of NAD+, a coenzyme crucial for energy metabolism and cellular function [4]