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This relationship can be rationalized by the similar chemical mechanism, involving an aromatic nucleophilic attack by the sulfur of glutathione to form a Meisenheimer -complex, which is followed by the release of the common conjugate S-2,4-dinitrophenylglutathione

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(2016) reported that oral administration of creatine (150 mg/kg BW per day) for 10 consecutive days resulted in significant regression of tumor size in Sarcoma-180 tumor-bearing mice and improved the overall survival of the animals