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This routine has been specially developed to meet the needs of Black, mixed-race, and melanin-rich skin, which is more prone to hyperpigmentation

It inhibits the thioredoxin-interacting protein (TXNIP), a key regulator of ROS production, which in turn downregulates the NLRP3 inflammasome, reducing inflammation and oxidative stress-induced tissue damage

As asthma medications, salbutamol and formoterol are permitted to be taken below certain specified doses and therefore are classed as Threshold Substances

The recommended schedule from clinical trials is: Weeks 1-4: 2.5 mg once weekly Weeks 5-8: 5 mg once weekly Weeks 9-12: 7.5 mg once weekly Weeks 13-16: 10 mg once weekly Weeks 17-20: 12.5 mg once weekly Week 21+: 15 mg once weekly (maximum dose) Not everyone follows this exact schedule